Histone Database

http://genome.nhgri.nih.gov/histones

Sullivan, S.¹, Sink, D.W.², Trout, K.L.², Makalowska, I.², Taylor, P.M.¹, Baxevanis, A.D.², Landsman, D.¹

¹Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 45, Room 6AN12J 45 Center Drive, MSC 6510 Bethesda, MD 20892-6510, U.S.A.
²Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A-22 Bethesda, MD 20892-4470, U.S.A.

Contact landsman@ncbi.nlm.nih.gov

Database Description

Histone proteins are often noted for their high degree of sequence conservation. It is less often recognized that the histones are a heterogeneous protein family. Furthermore, several classes of nonhistone proteins containing the histone fold motif exist. Novel histone and histone-fold protein sequences continue to be added to public databases every year. The Histone Database (http://genome.nhgri.nih.gov/histones/) is a searchable, periodically updated collection of histone-fold containing sequences derived from sequence-similarity searches of public databases. Sequence sets are presented in redundant and nonredundant FASTA form, hotlinked to GenBank sequence files. Partial sequences are also now in included in the database, which has considerably augmented its taxonomic coverage. Annotated alignments of full-length nonredundant sets of sequences are now available in both Web-viewable (HTML) and downloadable (PDF) formats. The database also provides summaries of current information on solved histone fold structures, post-translational modifications of histones, and the human histone gene complement.

REFERENCES

The Histone Database.
Sullivan S, Sink DW, Trout KL, Makalowska I, Taylor PM, Baxevanis AD, Landsman D.
Nucleic Acids Res 2002 Jan 1;30(1):341-2
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis t_uids=11752331&dopt=Abstract