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Mulder, N.J.1, Apweiler, R.1, Attwood, T.K.2, Bairoch, A.3, Bateman, A.4, Binns, D.1, Biswas, M.10, Bradley, P.1, Bork, P.8, Bucher, P.5, Copley, R.R.11, Courcelle, E.6, Das, U.1, Durbin, R.4, Falquet, L.5, Fleischmann, W.1, Griffiths-Jones, S.4, Haft, D.9, Harte, N.1, Hermjakob, H.1, Hulo, N.3, Kahn, D.6, Kanapin, A.1, Krestyaninova, M.1, Lopez, R.1, Letunic, I.8, Lonsdale, D.1, Silventoinen, V.1, Orchard, S.E.1, Pagni, M.5, Peyruc, D.6, Ponting, C.P.7, Selengut, J.D.9, Servant, F.1, Sigrist, C.J.A.3, Vaughan, R.1, Zdobnov, E.M.8
1EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
2School of Biological Sciences and Department of Computer Science, The University of Manchester, Manchester, UK.
3Swiss Institute for Bioinformatics, Geneva, Switzerland.
4Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
5Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland.
6CNRS/INRA, Toulouse, France.
7MRC Functional Genetics Unit, Department of Human Anatomy & Genetics, University of Oxford, UK.
8Biocomputing Unit EMBL, Heidelberg, Germany.
9The Institute for Genomic Research, Maryland, USA.
10ViaLactia Biosciences, Newmarket Auckland, New Zealand.
11Wellcome Trust Centre for Human Genetics, Oxford, UK.
Contact mulder@ebi.ac.uk
InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase in nearly 15% since the conception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).
There have been a number of improvements to the InterPro database since its conception, including increased coverage, additional features of the search tools, and a new look web interface.
The InterPro project is supported by the ProFuSe grant (number QLG2-CT-2000-00517) of the European Commission.
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Category Protein Databases
Go to the abstract in the NAR 2003 Database Issue.