Go to the abstract in the NAR 1999 Database Issue.
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1Department of Plant and Microbial Biology 461 Koshland Hall University of California Berkeley, CA 94720-3102
2Room D-109, Fairchild Building Stanford University School of Medicine Stanford, CA 94305
Contact brenner@compbio.berkeley.edu
Structural genomics aims to provide an experimental structure or good computational model for every tractable protein in completely sequenced genomes. Several research groups and centers are focused on providing high-throughput structure predictions and three-dimensional characterizations. The Presage database is a collaborative resource for structural genomics. It provides a central repository for distributing information about experimental work in progress, in order to avoid duplicate efforts between different groups and to keep the community aware of the centers’ progress. In addition, the availability of structural prediction information provided by several groups allows biologists to develop structural interpretations for their proteins of interest. The database is intended to enhance communications among structural genomics researchers and aid dissemination of their results.
Several new search criteria for protein sequences can be expressed, such as having annotations in certain date ranges and having/not having structures in the Protein Data Bank (PDB). Also, participating structural genomics centers have agreed on a common data format and method for disseminating information about the protein targets on which they are working experimentally, and this information is collected and integrated into Presage as experimental annotations.
PRESAGE is supported by NIH grant 1 R01 GM62621, NSF grant DBI-0002623, the Alfred P. Sloan Foundation, and DOE grant DE-FG-03-95ER62135.
Brenner SE, Barken D, Levitt M. 1999. The PRESAGE database for structural genomics. Nucleic Acids Research. 27:251-253.
Category Structure
Go to the abstract in the NAR 1999 Database Issue.