Imprinted Genes and Parent-of-Origin Effects

http://www.otago.ac.nz/IGC

Contact ian.morison@stonebow.otago.ac.nz

Database Description

The database of imprinted genes and parent-of-origin effects in animals (http://www.otago.ac.nz/IGC) is a collation of genes and phenotypes for which parent-of-origin effects have been reported. The database currently includes over 260 entries, which describe over 40 imprinted genes in human, mouse and other animals. In addition a wide variety of other parent-of-origin effects, such as transmission of human disease phenotypes, transmission of QTLs, uniparental disomies, and interspecies crosses are recorded. Data is accessed through a search engine and references are hyperlinked to PubMed.

Recent Developments

We have added a new section to the database which summarizes imprinting and functional information about the imprinted genes. These detailed entries integrate across species. For example, there are multiple entries for IGF2 (for each species), but only one detailed entry. The detailed entries were derived from the recent publication by Tycko and Morison (see below).

Acknowledgements

Croydon Paton designed the site and Susan Cleverley provides ongoing support.

REFERENCES

Morison IM, Paton CJ, Cleverley SD. The
imprinted gene and parent-of-origin effect
database. Nucleic Acids Research
2001;29:275-276.
Morison IM, Reeve AE. A catalogue of
imprinted genes and parent-of-origin effects in
animals. Human Molecular Genetics
1998;7:1599-1609.
Tycko B, Morison IM. Physiological functions of
imprinted genes. Journal of Cellular
Physiology 2002;192:245-58