Go to the abstract in the NAR 2001 Database Issue.
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1Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania
2Department of Pediatrics and Genetics, University of Pennsylvania
Contact vcheung@mail.med.upenn.edu
GenMapDB (http://genomics.med.upenn.edu/genmapdb) is a database of mapped human BAC clones that span the genome at about 1-Mb intervals. It serves as a clone resource for mapping studies such as fine-mapping of candidate gene regions, array-based genomic mismatch scanning and cytogenetic analyses. It contains experimentally-validated information for over 4,000 BAC clones from the RPCI-11 human BAC library. The genomic locations of the clones are obtained by STS-based mapping and validated by high-resolution fluorescent in situ hybridization. Additional information including HindIII fingerprints and BAC end sequences are also available. Recent development focuses on anchoring the BAC clones onto the human genome sequence assembly by alignment of the BAC end sequences to the genomic sequences. Results of those alignments are available on GenMapDB and the UCSC genome browser. The link to the UCSC genome browser provides additional annotations such as gene content and identity of neighboring clones.
1. Alignment of the mapped human BAC clones onto the UCSC genome sequence assembly. 2. Annotation of the mapped BAC clones to identify the genes that reside in them.
We thank Terry Furey and David Haussler for help in sequence alignment and Ilan Kirsch for cytogenetic analyses of the mapped clones.
Category Genetic and Physical Maps
Go to the abstract in the NAR 2001 Database Issue.