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Unit of Molecular Carcinogenesis, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, 69372 Lyon cedex 08, France
Contact p53database@iarc.fr
Mutations in the tumor suppressor gene TP53 are frequent in most human cancers. Comparison of the mutation patterns in different cancers may reveal clues on the natural history of the disease. Over the past ten years, several databases of TP53 mutations have been developed. The most extensive of these databases is maintained and developed at the International Agency for Research on Cancer. The database compiles all mutations (somatic and inherited), as well as polymorphisms, that have been reported in the published literature since 1989. The aim of the IARC TP53 mutation database is to provide an electronic format to retrieve, sort and analyse mutations in order to determine mutation patterns in human cancers. The IARC TP53 mutation dataset is the largest dataset available on the variations of any human gene. The database is available at http://www.iarc.fr/P53/.
Recent developments include: - restructuring of the database which is now patient-centered, with more detailed annotations on the patient (carcinogen exposure, virus infection, genetic background). - data on mutation prevalence (R6 update) and on clinical outcome (next update). - an online search system that allows the online analysis of somatic mutation data (available through the 'database search' option). This ASP (Active Server Pages) application allows the identification and selection of specific sets of data according to user's queries and produces graphical outputs (histograms and pie charts) of mutation patterns, codon distribution and tumor spectrum. A search of reference criteria (author name, PubMed entry, title, etc...) allows the analysis of mutation data by individual publication to generate graphs and figures. - the entire dataset, or sets of data selected according to the user?s queries, can be downloaded as tab-delimited text files, in a compressed format. - a comprehensive user guide is available online as well as a slide-show on TP53 mutations, database structure/content and examples of mutation analysis.
The project is funded by IARC and supported by the European Community (contract: QLG1-1999-00273).
Olivier M, Eeles R, Hollstein M, Khan MA, Harris C.C, Hainaut P. The IARC TP53 Database: new online mutation analysis and recommendations to users. Hum Mutat 2002 Jun;19(6):607-14
Hernandez-Boussard T, Montesano R, Hainaut P. Sources of bias in the detection and reporting of p53 mutations in human cancer: analysis of the IARC p53 mutation database. Genet Anal. 1999;14(5-6):229-33.
Category Mutation Databases
Go to the abstract in the NAR Database Issue.